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Nanotechnology For Drug Delivery and Tissue Bioengineering This program was originally presented as a Special Topic Session at the ARVO Annual Meeting on May 1, 2006 in Fort Lauderdale, Florida. There is increasing recognition that interdisciplinary sessions at ARVO, focusing on themes or processes in various systems that are common to two or more sections, have the potential to lead to highly productive intellectual syntheses and enhance cross-fertilization between fields. It is widely felt that conceptual productivity at the level of paradigm shift-type thinking arises from translocating established and developing ideas and technologies into new areas in which new applications can be developed. The National Eye Institute is currently emphasizing the importance of the possibilities of the applications nanotechnology to ophthalmology. We have unparalleled access to our target surgical tissue and already have a microsurgical environment that need only be modified to create a nanosurgical environment. We envision several applications of nanotechnology to ophthalmology: 1. Hydraulics/biomechanics: Some of our most troubling surgical problems may be analogized to hydraulic engineering problems (e.g., glaucoma, retinal vascular surgery). We need to bring ophthalmology to the point at which interventional radiology currently stands. 2. Drug delivery: We have very antiquated means of delivering drugs to our target tissue. It is inefficient and unnecessarily risky for patients to take eye drops or for patients to receive intravitreal injections of medicine. We know from studies of retinal rescue that constant drug delivery allows a greater therapeutic effect with lower drug levels than the traditional dosing methods. Nanotechnology is beautifully suited to provide constant drug delivery to the eye in several different settings. 3. Neural prosthetics: Current flow is a major problem for existing retinal prosthetic devices. The electrodes of retinal stimulation devices are quite large, which also limits image resolution. Electrodes the size of neurons would be better suited for these microelectrode arrays. We hope that this meeting will be a catalyst that motivates ophthalmologists to become involved in the transfer of nanoengineering capability into the eye. The speakers will lead us into this new environment. For them, there will be new opportunities for collaboration and intellectual exchange. Because many ophthalmic diseases are age-related and because our society is aging rapidly, the economic impact of these innovations could be quite large. For more information, logon to www.arvo.org or call 240-221-2900. Sessions include:
Presented by: Paul A. Sieving, MD, PhD Director National Eye Institute Bethesda, Maryland, USA Running time: 00:07:24 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts The Therapeutic Potential of Dendrimers in Diseases of the Eye Presented by: Sunil Shaunak, MD, PhD, FRCP, FRCPE Medicine Imperial College London Hammersmith Hospital London, United Kingdom Running time: 00:16:54 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts The Role of Nanotechnology in Genetics and Genomics Presented by: Julia E. Richards, PhD Associate Professor Department of Ophthalmology and Visual Sciences Department of Epidemiology The University of Michigan Running time: 00:12:29 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts Applications of Nanotechnology to Gene Delivery in Ophthalmology Presented by: Muna Naash, PhD Department of Cell Biology University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, USA Running time: 00:15:26 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts Role of Nanotechnology in Retinal Repair Presented by: Michael Young, PhD Schepens Eye Research Institute Department of Ophthalmology Harvard Medical School Boston, Massachusetts, USA Running time: 00:19:39 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts Creation of Micro-Nanotools for Nanomedicine Presented by: George D. Skidmore, PhD Device Scientist DRS Infrared Technologies Running time: 00:12:26 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts Modulation of Fundamental Cell Behaviors by Nanoscale Topographic Cues Presented by: Christopher Murphy, DVM, PhD University of Wisconsin-Madison Madison, Wisconsin, USA Running time: 00:18:34 View Presentation (Windows Compatible) View Presentation (Mac Compatible) View Transcripts
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